品名：cGMP 重组人白介素21

货号：AK9833

描述：Akron cGMP Recombinant Human Interleukin-21, rHu IL-21, cGMP IL21

Akron cGMP IL-21 Documents

Safety Data Sheet (SDS)
Product Page
Frequently Asked Questions (FAQ)

重组人白细胞介素21 （IL21，白细胞介素-21，interleukin-21，IL-21），由活化的CD4+T细胞分泌，分子结构与IL-15相似，参与调节B细胞增殖，协同IL-15促进骨髓前体细胞增殖和NK细胞增殖、分化和细胞毒活性。IL-21可增强抗CD40介导的增殖而抑制抗免疫球蛋白M（IgM）和IL-4诱导的增殖IL-21是作用于B细胞的一类免疫抑制因子, 可以抑制B细胞淋巴瘤细胞亚群的增殖, IL-21也可能在调节B细胞肿瘤发生方面具有作用。

描述：Recombinant Human Interleukin-21 (rHu IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15. The IL-21 receptor (IL-21-R) is expressed on T, B, and NK cells.

Aliquot Sizes & Formats

Lyophilized (40 μg) Cat. # AK9833-0040

CAR-T细胞培养，免疫细胞培养应用，Akron cGMP 细胞因子

cGMP IL-2, cGMP 重组人白介素2
cGMP IL-7, cGMP 重组人白介素7
cGMP IL-15, cGMP 重组人白介素12
cGMP IL-15, cGMP 重组人白介素15
cGMP IL-21, cGMP 重组人白介素21  

Source:  E. coli 

 IL-21 DMF No.: 32442

Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple antibody classes in vivo. IL-21-R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells. rHu IL-21 produced in E. coli is a single, non-glycosilated polypeptide chain that contains 133 amino acids and has a total molecular mass of 15.46 kDa.